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Course Information
3rd Annual Symposium
Clinical Applications of Genome-Wide Testing

Neuroscience Research Building
Auditorium (NRB)
UCLA Campus
Los Angeles, California
January 24, 2014 to January 24, 2014

Download: [ Brochure ]

Course Description

The UCLA Clinical Genomics Centerís 3rd Annual Symposium will provide important information about the appropriate clinical application of whole genome technologies including whole exome sequencing and Single-Nucleotide Polymorphism (SNP) chromosomal microarray analysis. A distinguished roster of speakers will discuss how these technologies are used to identify specific mutations in particular Mendelian and somatic disorders. Experts in a variety of disorders will highlight examples of improved patient outcomes using these definitive diagnostic approaches. The event will include a discussion of the highly complex ethical considerations associated with this extraordinary diagnostic opportunity and its impact and a mock case evaluation by the Exome Sequencing Genomic Data Board.

Target Audience

This course is targeted to adult and pediatric specialists in cardiology, neurology, oncology, ophthalmology, psychiatry, and neonatology; general and fetal medicine obstetricians; clinical and molecular geneticists; genetics counselors; molecular pathologists; clinical laboratory scientists; and pathologists, clinicians, fellows and residents with an interest in genomic medicine.

Registration Information



To enroll click here

By Mail

Send the completed enrollment form to:

Office of Continuing Medical Education
David Geffen School of Medicine at UCLA
Clinical Applications of Genome-Wide Testing
10920 Wilshire Blvd., Suite 1060
Los Angeles, CA 90024-6512

By Fax

Fax the enrollment form with charge card information and your authorizing signature to the Office of Continuing Medical Education, David Geffen School of Medicine at UCLA at (310) 794-2624

By Phone

Use your MasterCard, VISA, American Express or Discover Card. Call (310) 794-2620.

Registration Fee

  • $125 - General
  • $75 - Genetic Counselors
  • $35 - Fellows/Residents/Students

Cancellations must be received in writing by Friday, January 3, 2014 and will be subject to a $50 processing fee. No refunds will be granted after that date. If, for any reason, the course must be cancelled, discontinued, or rescheduled by the Office of Continuing Medical Education, a full refund will be provided.

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Course Chair

Wayne W. Grody, MD, PhD, FACMG, FCAP
Professor of Pathology and Laboratory Medicine, Pediatrics, and Human Genetics*
Director, UCLA Molecular Diagnostics Laboratories
Director, Clinical Genomics Center

Course Co-Chair

Fabiola Quintero-Rivera, MD, FACMG
Assistant Professor*
Department of Pathology and Laboratory Medicine
Associate Director, Clinical and Molecular Cytogenetics Laboratory
UCLA Clinical Genomics Center
UCLA Health System

Guest Faculty

Elaine Mardis, PhD
Professor, Department of Genetics
Adjunct Professor, Department of Molecular Microbiology
Co-Director, The Genome Institute
Washington University School of Medicine

UCLA Faculty

Vivian Y. Chang, MD, MS
Clinical Instructor*
Division of Pediatric Hematology/Oncology
Department of Pediatrics
Mattel Children's Hospital UCLA

Kingshuk Das, MD
Assistant Professor*
Associate Medical Director, UCLA Clinical Laboratories
Director of Operations, Genetic Medicine
Department of Pathology and Laboratory Medicine

Josh Deignan, PhD, FACMG
Assistant Professor*
Associate Director, UCLA Molecular Diagnostics Laboratories
Associate Director, UCLA Orphan Disease Testing Center
Department of Pathology and Laboratory Medicine

Naghmeh Dorrani, MS, LCGC
Certified Genetics Counselor*
Department of Pediatrics

Michelle Fox, MS, LCGC
Adjunct Associate Professor of Pediatrics*

Ariadna Martinez, MS, MS, LCGC
Certified Genetics Counselor*
Jules Stein Eye Institute

Stanley F. Nelson, MD
Departments of Human Genetics, Pathology and Laboratory Medicine, and Psychiatry

Perry Shieh, MD, PhD
Associate Professor of Neurology*
Director, Neuromuscular Program

* David Geffen School of Medicine at UCLA

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Program Agenda

Friday, January 24, 2014

8:15 Registration/Continental Breakfast
9:00 Welcome
A. Eugene Washington, MD, MSc
9:10 Keynote Address: NGS-Based Cancer Genomics: Discovery and Translation
Elaine Mardis, PhD
9:55 Keynote Questions and Answers
10:10 Exome Sequencing in Pediatric Cancer Predisposition-From Diagnosis to Novel Discovery
Vivian Y. Chang, MD, MS
10:35 Questions and Answers
10:40 The End of the Diagnostic Odyssey, But What Does the Patient Say?
Naghmeh Dorrani, MS, LCGC; Michelle Fox, MS , LCGC; Ariadna Martinez, MS, MS, LCGC
11:05 Questions and Answers
11:10 Break
11:40 Clinical Next Generation Sequencing: Current Guidelines for Testing, Analyzing, and Reporting
Josh Deignan, PhD, FACMG
12:05 Questions and Answers
12:10 Reporting of Incidental Findings in Clinical Genome-Level Sequencing: The Ethical Dilemma That Just Won't Go Away
Wayne W. Grody, MD, PhD, FACMG, FCAP
12:35 Questions and Answers
12:40 Lunch
1:45 Clinical Exome Sequencing: Efficient Medical Diagnosis
Stanley F. Nelson, MD
2:10 Questions and Answers
2:15 Current Trends in Prenatal Diagnosis: From Non-Invasive Screening to Invasive Genome-Wide Testing
Fabiola Quintero-Rivera, MD, FACMG; Kingshuk Das, MD
2:40 Questions and Answers
2:45 Diagnosing Inherited Neuromuscular Conditions: Capturing What We Know, What We Donít, and Everything in Between
Perry Shieh, MD, PhD
3:10 Questions and Answers
3:15 Break
3:45 Mock Case Discussion-Exome Case
5:10 Closing Remarks
Wayne W. Grody, MD, PhD, FACMG, FCAP
5:30 Adjourn

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Goals and Objectives

At the conclusion of this course participants should be able to:

  • Discuss appropriate application of genome-wide analysis within clinical practice and become aware of how and where to access these services.
  • Explore specific diagnostic strategies for Mendelian disorders and assessment of cancer predisposition disorders.
  • Understand the clinical application of new technologies for prenatal genetic diagnosis.
  • Develop a better understanding of the complex ethical considerations and reporting challenges presented by these genome-wide technologies.

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The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA designates this live activity for a maximum of 6.25 AMA PRA Category 1 Credits TM. Physicians should claim only credit commensurate with the extent of their participation in the activity.

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The FDA has issued a concept paper which classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is "truly independent" and free of commercial influence. In addition to independence, the FDA requires that nonpromotional, commercially supported education be objective, balanced, and scientifically rigorous. The policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program's participants. In addition, Accreditation Council for Continuing Medical Education policy now mandates that the provider adequately manages all identified potential conflicts of interest prior to the program. We at UCLA fully endorse the letter and spirit of these concepts.

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Several hotels are located within walking distance of the course venue. When making your reservation, request the UCLA group rate.

The W Hotel
930 Hilgard Avenue
Los Angeles, CA 90024
(310) 208-8765

Hotel Palomar
10740 Wilshire Boulevard
Los Angeles, CA 90024
(310) 475-8711
$180 & up/night

Hilgard House
927 Hilgard Avenue
Los Angeles, CA 90024
(866) 539-0036

Directions and Parking

From the 405 freeway, exit on Wilshire Blvd. East. Proceed on Wilshire Blvd. to Westwood Blvd. and make a left. Proceed north on Westwood Blvd., turn right on Charles E. Young Drive South and continue ½ a block. Turn left into Lot 9. There will be an attendant selling permits from 7:30 am-9:30 am. If you arrive outside of this time frame please report to the parking kiosk on Westwood Plaza to pay for your parking permit.

Parking is $12 daily

Additional Information

If you have any questions, please contact the UCLA Office of Continuing Medical Education at 310-794-2620.

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